Bills vs Rams Thursday Night Football Picks and Predictions: Opening Night Theatrics Dull Offenses

We welcome back NFL betting with a bang — and a potential Super Bowl preview — when the Buffalo Bills visit the Los Angeles Rams on Thursday Night Football in Week 1.

The Bills have high hopes for 2022, climbing to the top of the Super Bowl odds this offseason while also winning over early-bird bettors, who have moved Buffalo from a +1 underdog to a 2.5-point favorite on the road in SoFi Stadium.

The Rams are rare underdogs — especially for a defending champ at home in the season opener — and finished 3-0 ATS as pups last season, owning an all-time 11-8 ATS count as underdogs under Sean McVay. 

The NFL’s food chain gets figured out when these apex predators collide in a non-conference clash. Here are our best NFL picks and predictions for Bills at Rams.

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